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- Deep facial wrinkles and folds
- Nasolabial folds, also known as smile lines, are the lines that run from the sides of the nose to the corners of the mouth
- Marionette lines, which are the lines that run from the corners of the mouth down toward the chin
- Chin wrinkles
- Volume loss in the cheeks
- Hollows or indents in the skin due to aging or weight loss
- Facial lipoatrophy, a condition that causes loss of fat under the skin, leading to sunken cheeks or indentations
- Overall loss of skin firmness and elasticity
